	US 12,011,497 B2
	Compounds, compositions containing same, and use thereof for promoting hair growth
Yeo Joon Yoon, Seoul (KR); Eunji Cheong, Seoul (KR); Seung-Woo Cho, Seoul (KR); Myoung-Chong Song, Seoul (KR); Ji Yoon Beom, Seoul (KR); Jin A Jung, Seoul (KR); Jong Seung Lee, Seoul (KR); and Heon-Joo Lee, Seoul (KR)
Assigned to Molgenbio Co. Ltd., Seoul (KR)
Appl. No. 17/413,358
Filed by Molgenbio Co. Ltd., Seoul (KR)
PCT Filed Dec. 11, 2019, PCT No. PCT/KR2019/017523 § 371(c)(1), (2) Date Jun. 11, 2021, PCT Pub. No. WO2020/122611, PCT Pub. Date Jun. 18, 2020.
Claims priority of application No. 10-2018-0158863 (KR), filed on Dec. 11, 2018; and application No. 10-2019-0086645 (KR), filed on Jul. 17, 2019.
Prior Publication US 2022/0257488 A1, Aug. 18, 2022
Int. Cl. A61K 8/49 (2006.01); A23L 29/00 (2016.01); A23L 33/10 (2016.01); A61K 31/407 (2006.01); A61K 31/436 (2006.01); A61P 17/14 (2006.01); A61Q 7/00 (2006.01)

CPC A61K 8/4926 (2013.01) [A23L 29/045 (2016.08); A23L 33/10 (2016.08); A61K 31/407 (2013.01); A61K 31/436 (2013.01); A61P 17/14 (2018.01); A61Q 7/00 (2013.01)]

11 Claims

1. A method of promoting hair growth or treating hair loss, the method comprising a step of administering to a subject a pharmaceutically effective amount of a compound selected from the group consisting of 9-deoxo-31-O-demethyl-prolyl-FK506 represented by Formula 1 below, 9-deoxo-36,37-dihydro-FK506 represented by Formula 2 below, 31-O-demethyl-36,37-dihydro-FK506 represented by Formula 3 below, 9-deoxo-31-O-demethyl-36,37-dihydro-FK506 represented by Formula 4 below, 9-deoxo-FK520 represented by Formula 5 below, 31-O-demethyl-FK520 represented by Formula 6 below, 9-deoxo-31-O-demethyl-FK520 represented by Formula 7 below, 9-deoxo-FK523 represented by Formula 8 below, and 9-deoxo-31-O-demethyl-FK523 represented by Formula 9 below, or a pharmaceutically acceptable salt thereof:

wherein the compound has reduced immunosuppressive activity compared to FK506.