US 12,011,486 B2
MOMP telonanoparticles, and related compositions, methods and systems
Matthew A. Coleman, Oakland, CA (US); Nicholas O. Fischer, Livermore, CA (US); Amy Rasley, Livermore, CA (US); Craig D. Blanchette, San Leandro, CA (US); and Todd Peterson, Coronado, CA (US)
Assigned to LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, Livermore, CA (US)
Filed by LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, Livermore, CA (US)
Filed on Dec. 23, 2021, as Appl. No. 17/561,625.
Application 17/561,625 is a continuation of application No. 16/609,420, granted, now 11,207,422, previously published as PCT/US2018/030537, filed on May 1, 2018.
Claims priority of provisional application 62/500,435, filed on May 2, 2017.
Prior Publication US 2022/0211866 A1, Jul. 7, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/00 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 39/02 (2006.01); A61K 39/39 (2006.01); A61K 47/69 (2017.01); A61P 31/04 (2006.01); B82Y 5/00 (2011.01)
CPC A61K 47/6915 (2017.08) [A61K 9/0019 (2013.01); A61K 9/0043 (2013.01); A61K 9/1273 (2013.01); A61K 9/1277 (2013.01); A61K 39/0208 (2013.01); A61K 39/39 (2013.01); A61P 31/04 (2018.01); B82Y 5/00 (2013.01); A61K 2039/54 (2013.01); A61K 2039/543 (2013.01); A61K 2039/545 (2013.01); A61K 2039/6018 (2013.01); A61K 2039/6093 (2013.01)] 31 Claims
 
1. A telodendrimer-nanolipoprotein particle (t-NLP), comprising
one or more membrane forming lipids,
one or more telodendrimers,
one or more adjuvants, and
a scaffold protein and a Chlamydia major outer membrane protein (MOMP) and/or a fragment thereof comprising a MOMP hydrophobic region,
wherein the one or more membrane forming lipids are arranged in a discoidal membrane lipid bilayer stabilized by the scaffold protein and the one or more telodendrimers, with the membrane lipid bilayer attaching
the MOMP and/or the fragment thereof through interaction of the hydrophobic region with the membrane lipid bilayer and
the one or more adjuvants through binding of the one or more adjuvants to the discoidal membrane bilayer or to a component thereof.