	US 12,011,483 B2
	Liquid delivery composition
Franca Ferrari, Pavia (IT); Cristina Bonferoni, Pavia (IT); Giuseppina Sandri, Pavia (IT); Luigi Maria Longo, Lainate (IT); Cristina Macelloni, Lainate (IT); and Silvia Rossi, Pavia (IT)
Assigned to COSMO TECHNOLOGIES LTD., Dublin (IE)
Appl. No. 16/956,872
Filed by COSMO TECHNOLOGIES LTD., Dublin (IE)
PCT Filed Dec. 20, 2018, PCT No. PCT/EP2018/086424 § 371(c)(1), (2) Date Jun. 22, 2020, PCT Pub. No. WO2019/122253, PCT Pub. Date Jun. 27, 2019.
Claims priority of application No. 17210119 (EP), filed on Dec. 22, 2017.
Prior Publication US 2021/0154300 A1, May 27, 2021
Int. Cl. A61K 9/08 (2006.01); A61K 9/00 (2006.01); A61K 9/107 (2006.01); A61K 35/33 (2015.01); A61K 47/10 (2017.01); A61K 47/34 (2017.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); A61P 17/02 (2006.01)

CPC A61K 47/34 (2013.01) [A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 9/1075 (2013.01); A61K 35/33 (2013.01); A61K 47/10 (2013.01); A61K 47/38 (2013.01); A61P 17/02 (2018.01)]

11 Claims

1. A composition for use as a delivery vehicle comprising at least one thermo-responsive polymer, at least one ion-sensitive polymer, and at least one bio-adhesive polymer in a liquid formulation, wherein the at least one thermo-responsive polymer comprises 0.3-25% (w/w) poloxamer 407, the at least one ion-sensitive polymer comprises 0.01-2.0% (w/w) sodium alginate, and the at least one bio-adhesive polymer comprises 0.01-2.0% (w/w) sodium carboxymethylcellulose, wherein the composition comprises at least one active substance for delivery, wherein the at least one active substance comprises: monoclonal antibodies, anti-acids, adrenergic drugs, anti-adrenergic drugs, dyes, steroidal and non-steroidal anti-inflammatory drugs, nasal antihistamines, nasal decongestants, anti-neoplastics, antimicrobics, antibiotics, antifungal drugs, genitourinary tract agents, vaginal agents, vaginal antifungal, vaginal antibiotics, oral cavity disinfectants or oral cavity antibiotics, wound healing drugs, haemostatics, anaesthetics, or a mixture thereof;

wherein the composition is formulated such that an active substance can be added at the time of administration.