US 12,011,456 B2
Intradialytic use of sodium nitrite
Craig Sherman, Scottsdale, AZ (US)
Assigned to Hope Medical Enterprises, Inc., Scottsdale, AZ (US)
Filed by Hope Medical Enterprises, Inc., Scottsdale, AZ (US)
Filed on Jan. 3, 2023, as Appl. No. 18/092,569.
Application 18/092,569 is a continuation of application No. 17/102,411, filed on Nov. 23, 2020, granted, now 11,564,938.
Application 17/102,411 is a continuation of application No. 16/403,428, filed on May 3, 2019, granted, now 10,898,512, issued on Jan. 26, 2021.
Application 16/403,428 is a continuation of application No. 15/914,353, filed on Mar. 7, 2018, granted, now 10,328,099, issued on Jun. 25, 2019.
Claims priority of provisional application 62/468,857, filed on Mar. 8, 2017.
Prior Publication US 2023/0256005 A1, Aug. 17, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 33/00 (2006.01); A61M 1/16 (2006.01); A61P 13/12 (2006.01)
CPC A61K 33/00 (2013.01) [A61M 1/1654 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method for maintaining physiological levels of nitrite in a subject undergoing hemodialysis; reducing the risk of myocardial infarction in a subject undergoing dialysis; reducing the risk of sudden cardiac death in a subject undergoing dialysis; reducing the risk of stroke in a subject undergoing dialysis; reducing the risk of cardiovascular disease that is characterized by tissue ischemia in a subject undergoing dialysis; reducing the risk of high blood pressure in a subject undergoing dialysis; reducing the risk of pulmonary hypertension in a subject undergoing dialysis; or reducing the risk of renal hypertension in a subject undergoing dialysis, comprising intradialytically contacting said subject's blood with a dialyzer membrane that is also in contact with a nitrite-spiked dialysate, wherein an aqueous solution comprising sodium nitrite is added to an unspiked dialysate as the unspiked dialysate flows from a dialysis machine to a dialyzer membrane, wherein said unspiked dialysate comprises a mixture of water, an acid concentrate solution, and a bicarbonate concentrate solution, and wherein said nitrite-spiked dialysate has a pH greater than about 7.0, and further comprising administering to said subject one or more medications and/or vitamins.