US 12,011,433 B2
Mofezolac derivatives as multi-functions selective COX-1 inhibitors
Antonio Scilimati, Bari BA (IT); Maria Grazia Perrone, Bari BA (IT); and Paola Vitale, Bari BA (IT)
Assigned to ITEL Telecomunicazioni S.r.l., Ruvo di Puglia BA (IT)
Filed by UNIVERSITÁ DEGLI STUDI DI BARI “ALDO MORO”, Bari BA (IT); and ITEL Telecomunicazioni S.r.l., Ruvo di Puglia BA (IT)
Filed on Oct. 2, 2020, as Appl. No. 17/062,269.
Application 17/062,269 is a continuation of application No. 16/097,126, abandoned, previously published as PCT/IB2017/052395, filed on Apr. 26, 2017.
Claims priority of provisional application 62/328,604, filed on Apr. 27, 2016.
Prior Publication US 2021/0023055 A1, Jan. 28, 2021
Int. Cl. A61K 31/415 (2006.01); A61K 31/7024 (2006.01); A61P 37/06 (2006.01); C07D 261/08 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07H 13/04 (2006.01)
CPC A61K 31/415 (2013.01) [A61K 31/7024 (2013.01); A61P 37/06 (2018.01); C07D 261/08 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07H 13/04 (2013.01)] 12 Claims
 
1. A compound having formula I

OG Complex Work Unit Chemistry
wherein R is a linker selected from benzidine, phenylenediamine, α,α′-diamino-p-xylenealkyldiamine, O—(CH2)n, NH—(CH2)nCO, NH—(CH2)n or NH—(CH2)nNH, wherein n is from 0 to 12, and wherein G is a fluorescent moiety selected from nile blue and analogues thereof.