US 12,011,428 B2
Compositions and methods for stimulating ventilatory and/or respiratory drive
Stephen J. Lewis, Cleveland, OH (US); Michael W. Jenkins, Cleveland, OH (US); and James M. Seckler, Cleveland, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Filed on Mar. 16, 2022, as Appl. No. 17/696,204.
Prior Publication US 2023/0338319 A1, Oct. 26, 2023
Int. Cl. A61K 31/198 (2006.01); A61K 45/06 (2006.01); A61P 11/00 (2006.01)
CPC A61K 31/198 (2013.01) [A61K 45/06 (2013.01); A61P 11/00 (2018.01)] 9 Claims
 
1. A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof, the method comprising:
administering to the subject a therapeutically effective amount of a composition comprising a glutathione alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof, wherein the adduct of the glutathione alkyl ester is at least one of an albumin adduct, a glucose adduct, an L-cysteine adduct, a D-cysteine adduct, and an S-nitroso adduct.