US 12,011,315 B2
Intracranial blood pressure estimation method and device
Jonathan Thomas Sutton, Boston, MA (US); Raghavendra Srinivasa Naidu, Auburndale, MA (US); Shyam Bharat, Arlington, MA (US); Jonathan Fincke, Belmont, MA (US); Balasundar Iyyavu Raju, North Andover, MA (US); and Shriram Sethuraman, Lexington, MA (US)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Appl. No. 17/602,888
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Apr. 2, 2020, PCT No. PCT/EP2020/059332
§ 371(c)(1), (2) Date Oct. 11, 2021,
PCT Pub. No. WO2020/207883, PCT Pub. Date Oct. 15, 2020.
Claims priority of provisional application 62/832,077, filed on Apr. 10, 2019.
Prior Publication US 2022/0160327 A1, May 26, 2022
Int. Cl. A61B 8/04 (2006.01); A61B 8/00 (2006.01); A61B 8/06 (2006.01); A61B 8/08 (2006.01)
CPC A61B 8/04 (2013.01) [A61B 8/06 (2013.01); A61B 8/461 (2013.01); A61B 8/488 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for deriving an estimation of intracranial blood pressure via an ultrasound system, wherein the ultrasound system includes an ultrasound transducer and a processor, comprising:
obtaining a first signal from the ultrasound transducer; indicative of cerebral blood vessel wall movement as a function of time;
obtaining a second signal from the ultrasound transducer; indicative of cerebral blood flow velocity as a function of time;
obtaining a third signal, indicative of blood pressure at a location outside of the brain as a function of time,
the first, second and third signals corresponding to measurements over the same time period;
detecting a phase offset of the second signal with respect to the first; and
transforming the third signal by applying to the third signal a phase shift such that the third signal exhibits a phase offset with respect to the second signal of an amount equal to said detected phase offset, to thereby obtain a fourth signal indicative of estimated intracranial blood pressure.