US 12,011,302 B2
Method, system, and computer readable medium for generating pulse oximetry predictive scores (POPS) for predicting adverse outcomes in preterm infants
Karen D. Fairchild, Charlottesville, VA (US); Douglas E. Lake, Charlottesville, VA (US); and Brynne Sullivan, Charlottesville, VA (US)
Assigned to University of Virginia Patent Foundation, Charlottesville, VA (US)
Filed by University of Virginia Patent Foundation, Charlottesville, VA (US)
Filed on Dec. 21, 2020, as Appl. No. 17/129,695.
Application 17/129,695 is a continuation of application No. 15/801,226, filed on Nov. 1, 2017, granted, now 10,869,637, issued on Dec. 22, 2020.
Application 15/801,226 is a continuation in part of application No. PCT/US2017/030606, filed on May 2, 2017.
Claims priority of provisional application 62/330,463, filed on May 2, 2016.
Prior Publication US 2021/0106287 A1, Apr. 15, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/1455 (2006.01); G16H 15/00 (2018.01); G16H 50/30 (2018.01)
CPC A61B 5/7275 (2013.01) [A61B 5/1455 (2013.01); A61B 5/14551 (2013.01); A61B 5/48 (2013.01); G16H 50/30 (2018.01); A61B 2503/045 (2013.01); A61M 2230/205 (2013.01); G16H 15/00 (2018.01)] 14 Claims
OG exemplary drawing
 
1. A method for generating pulse oximetry predictive scores (POPS) for predicting occurrence of predetermined pathologies in a preterm infant, the method comprising:
based on Heart Rate (HR) and oxygen saturation (Sp02) data sensed directly from the preterm infant by a pulse oximetry sensor, calculating by at least one processor and over different time periods specific to a predetermined pathology one or more of:
(a) mean and standard deviation of HR and Sp02,
(b) cross-correlation of HR and Sp02,
(c) HR decelerations,
(d) HR and Sp02 entropy,
(e) hypoxia and hyperoxia, or
(f) any combination of (a) through (e);
generating by said at least one processor pulse oximetry predictive scores (POPS) via a predictive algorithm which incorporates cross-correlation of HR and Sp02 calculated on archived pulse oximetry data of multiple preterm infants to analyze the calculated data;
outputting said generated pulse oximetry predictive scores (POPS) on a display monitor to a user; and
predicting the predetermined pathology of said preterm infant based on the generated POPS, wherein the pathology includes at least one of intraventricular hemorrhage (IVH), late-onset sepsis (LOS), necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), or retinopathy of prematurity (ROP);
based on the outputting of the POPS, informing said user of an opportunity to perform an action selected from the group consisting of:
identifying said preterm infant as a highest risk infant and performing additional surveillance of or therapeutic intervention on said preterm infant;
identifying said preterm infant for participation in a clinical trial based on a risk profile associated with said POPS; and
treating said preterm infant for said pathology.