US 12,010,987 B2
Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
Waleed H. Hassanein, North Andover, MA (US); Tamer I. Khayal, North Andover, MA (US); Ahmed Elbetanony, North Andover, MA (US); Paul Lezberg, Westford, MA (US); Giovanni Cecere, Needham, MA (US); Dennis Sousa, Wakefield, MA (US); and Elizabeth Hansen Bulger, Portsmouth, NH (US)
Assigned to TRANSMEDICS, INC., Andover, MA (US)
Filed by TransMedics, Inc., Andover, MA (US)
Filed on Jan. 12, 2023, as Appl. No. 18/153,391.
Application 13/587,810 is a division of application No. 11/790,405, filed on Apr. 25, 2007, granted, now 8,304,181, issued on Nov. 6, 2012.
Application 18/153,391 is a continuation of application No. 16/916,514, filed on Jun. 30, 2020, granted, now 11,570,985.
Application 16/916,514 is a continuation of application No. 16/396,296, filed on Apr. 26, 2019, granted, now 10,736,314, issued on Aug. 11, 2020.
Application 16/396,296 is a continuation of application No. 15/857,953, filed on Dec. 29, 2017, granted, now 10,321,676, issued on Jun. 18, 2019.
Application 15/857,953 is a continuation of application No. 13/587,810, filed on Aug. 16, 2012, granted, now 9,894,894, issued on Feb. 20, 2018.
Application 11/790,405 is a continuation in part of application No. 11/246,902, filed on Oct. 7, 2005, granted, now 8,465,970, issued on Jun. 18, 2013.
Claims priority of provisional application 60/725,168, filed on Oct. 6, 2005.
Claims priority of provisional application 60/694,971, filed on Jun. 28, 2005.
Claims priority of provisional application 60/616,835, filed on Oct. 7, 2004.
Prior Publication US 2023/0210104 A1, Jul. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A01N 1/02 (2006.01)
CPC A01N 1/0247 (2013.01) [A01N 1/02 (2013.01); A01N 1/0273 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A method comprising:
receiving an ex vivo heart in a protective chamber of an organ care system;
pumping a perfusion fluid, via a perfusion circuit coupled to the ex vivo heart, into the ex vivo heart;
measuring an aortic pressure of the ex vivo heart;
obtaining a plurality of lactate differentials over time, wherein obtaining each lactate differential of the plurality of lactate differentials over time comprises:
measuring a first lactate value of the perfusion fluid in a first conduit, wherein the perfusion fluid in the first conduit is flowing into the ex vivo heart;
measuring a second lactate value of the perfusion fluid in a second conduit, wherein the perfusion fluid in the second conduit is flowing away from the ex vivo heart; and
subtracting the first lactate value of the perfusion fluid in the first conduit from the second lactate value of the perfusion fluid in the second conduit to obtain a lactate differential; and
correlating the plurality of lactate differentials over time and the aortic pressure with a transplantation suitability of the ex vivo heart, wherein at least two values of zero or less of the plurality of lactate differentials over time indicates that the ex vivo heart is suitable for transplantation.