US 12,334,328 B2
Synchronization of ion generation with cycling of a discontinuous atmospheric interface
Robert Graham Cooks, West Lafayette, IN (US); Guangtao Li, Carmel, IN (US); Guangming Huang, West Lafayette, IN (US); Jason Duncan, Dayton, IN (US); Xin Li, West Lafayette, IN (US); Ewa Sokol, West Lafayette, IN (US); and Xin Yan, West Lafayette, IN (US)
Assigned to Purdue Research Foundation, West Lafayette, IN (US)
Filed by Purdue Research Foundation, West Lafayette, IN (US)
Filed on Jun. 13, 2023, as Appl. No. 18/209,074.
Application 18/209,074 is a continuation of application No. 16/930,388, filed on Jul. 16, 2020, granted, now 11,699,580.
Application 16/930,388 is a continuation of application No. 16/260,924, filed on Jan. 29, 2019, granted, now 10,755,910, issued on Aug. 25, 2020.
Application 16/260,924 is a continuation of application No. 15/355,501, filed on Nov. 18, 2016, granted, now 10,361,073, issued on Jul. 23, 2019.
Application 15/355,501 is a continuation of application No. 14/052,815, filed on Oct. 14, 2013, granted, now 9,500,623, issued on Nov. 22, 2016.
Application 14/052,815 is a continuation in part of application No. 13/887,911, filed on May 6, 2013, granted, now 9,184,036, issued on Nov. 10, 2015.
Prior Publication US 2023/0420236 A1, Dec. 28, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. H01J 49/04 (2006.01); G01N 27/62 (2021.01); H01J 49/00 (2006.01); H01J 49/42 (2006.01)
CPC H01J 49/04 (2013.01) [G01N 27/62 (2013.01); H01J 49/0018 (2013.01); H01J 49/0031 (2013.01); H01J 49/0445 (2013.01); H01J 49/045 (2013.01); H01J 49/4205 (2013.01); Y10T 436/24 (2015.01)] 8 Claims
OG exemplary drawing
 
1. A method for monitoring a reaction in real-time, the method comprising:
providing an online reaction monitoring system that comprises a reaction vessel that comprises an outlet port; a channel that extends from within the outlet port; an electrode operably associated with a distal end of the channel; and a mass spectrometer;
selecting a solvent that is compatible as both a reaction solvent and an ionization solvent;
conducting a reaction in the solvent in the reaction vessel;
flowing a portion of the solvent from the reaction vessel through the channel;
generating ions of one or more analytes in the solvent by applying an electrical potential to a distal end of the channel via the electrode;
using the flowed portion of the solvent from the vessel as the ionization solvent; and
analyzing the ions in the mass spectrometer, thereby monitoring the reaction in real-time.