| CPC G06T 7/0002 (2013.01) [G06V 10/751 (2022.01); G06T 2207/10061 (2013.01); G06T 2207/20084 (2013.01); G06T 2207/30141 (2013.01)] | 19 Claims |

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1. A sample observation system comprising:
a scanning electron microscope; and
a calculator, wherein
the calculator:
(1) acquires a plurality of images captured by the scanning electron microscope;
(2) acquires, from the plurality of images, a learning defect image including a defect portion and a learning reference image not including the defect portion;
(3) calculates an estimation processing parameter by using the learning defect image and the learning reference image;
(4) acquires an inspection defect image including a defect portion; and
(5) estimates a pseudo reference image by using the estimation processing parameter and the inspection defect image, and
the process (3) includes:
(3A) aligning the learning defect image and the learning reference image based on a predetermined evaluation value to acquire an alignment amount;
(3B) cutting out a partial learning defect image from the learning defect image based on the alignment amount;
(3C) cutting out a partial learning reference image from the learning reference image based on the alignment amount; and
(3D) calculating the estimation processing parameter by using the partial learning defect image and the partial learning reference image.
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