US 12,333,073 B2
Systems and methods for multiplexed amplifiers for brain computer interfaces
Gabriella Shull, Durham, NC (US); Jonathan Viventi, Durham, NC (US); Thomas Jochum, Durham, NC (US); Hui Fang, Hanover, NH (US); and Michael Trumpis, Berkeley, CA (US)
Assigned to Duke University, Durham, NC (US); and The Trustees of Dartmouth College, Hanover, NH (US)
Filed by Duke University, Durham, NC (US); and The Trustees of Dartmouth College, Hanover, NH (US)
Filed on Oct. 13, 2023, as Appl. No. 18/486,735.
Claims priority of provisional application 63/415,758, filed on Oct. 13, 2022.
Prior Publication US 2024/0134452 A1, Apr. 25, 2024
Int. Cl. A61B 5/00 (2006.01); A61B 5/05 (2021.01); G06F 3/01 (2006.01)
CPC G06F 3/015 (2013.01) [G06F 2203/011 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A brain computer interface for interfacing with a brain of a subject, the brain computer interface comprising:
one or more shanks, wherein each shank comprises:
an array of pixels, wherein each pixel comprises:
an electrode; and
a front-end circuit positioned at a site of the electrode, the front-end circuit configured to reduce noise in signals recorded by the electrode, and the front-end circuit further configured to multiplex the signals,
wherein a density of power consumption of the each pixel is equal to or less than 1 μW per area of 50 μm by 50 μm; and
output traces electrically coupled with the array of pixels, wherein a number of output traces is less than a number of pixels in the array due to multiplexing,
wherein the one or more shanks are configured to be inserted on and/or into a brain of a subject.
 
12. A method of fabricating a brain computer interface for interfacing with a brain of a subject, comprising:
forming one or more shanks, wherein each shank includes:
an array of pixels, wherein each pixel includes:
an electrode; and
a front-end circuit at a site of the electrode, the front-end circuit is configured to reduce noise in signals recorded by the electrode, and the front-end circuit further configured to multiplex the signals,
wherein a density of power consumption of the each pixel is equal to or less than 1 μW per area of 50 μm by 50 μm; and
output traces electrically coupled with the array of pixels, wherein a number of output traces is less than a number of pixels in the array due to multiplexing,
wherein the one or more shanks are configured to be inserted on and/or into a brain of a subject; and
transferring the one or more shanks to a substrate.