US 12,332,258 B2
Dispensing device and method
Daisuke Hara, Tokyo (JP); Toshiki Yamagata, Tokyo (JP); and Masashi Shibahara, Tokyo (JP)
Assigned to HITACHI HIGH-TECH CORPORATION, Tokyo (JP)
Appl. No. 18/013,933
Filed by Hitachi High-Tech Corporation, Tokyo (JP)
PCT Filed Aug. 3, 2020, PCT No. PCT/JP2020/029640
§ 371(c)(1), (2) Date Dec. 30, 2022,
PCT Pub. No. WO2022/029826, PCT Pub. Date Feb. 10, 2022.
Prior Publication US 2023/0314455 A1, Oct. 5, 2023
Int. Cl. G01N 35/00 (2006.01); G01N 35/10 (2006.01)
CPC G01N 35/00623 (2013.01) [G01N 35/1011 (2013.01); B01L 2200/146 (2013.01); G01N 2035/00277 (2013.01); G01N 2035/1013 (2013.01); G01N 2035/1025 (2013.01); G01N 2035/103 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A dispensing device for suctioning a liquid sample with a dispensing tip and discharging a predetermined amount of the suctioned liquid sample to perform dispensing, the dispensing device comprising:
a pressure sensor configured to measure an internal pressure of the dispensing device;
a pipette mechanism comprising a piston and a receiving piston configured to perform suction and discharge;
an automatic drive stage to drive the dispensing device in a vertical direction;
a drive unit configured to drive the piston of the pipette mechanism, wherein the dispensing tip is mounted on the pipette mechanism and the drive unit is configured to drive the pipette mechanism in a suction or discharge direction; and
a control unit configured to:
control the drive unit based an output of the pressure sensor,
determine a type of the dispensing tip based on a pressure waveform measured by the pressure sensor while the pipette mechanism is performing suction or discharge, by:
driving the dispensing device with the automatic stage in the vertically downward direction while the piston is driven in the suction direction or in the discharge direction and while measuring the pressure with the pressure sensor,
detecting that the dispensing tip reaches a liquid level using the pressure measurements,
obtaining a slope of an approximate straight line of a pressure waveform obtained during a time while the drive unit is performing suction or discharge from the time of liquid level detection, and
comparing the slope of the approximate straight line with a value measured in advance, in order to determine the type of dispensing tip.