	US 12,332,256 B2
	Erythrocyte simulating particle, preparation method therefor, and quality control or calibrator containing same
Ruixia Song, Shenzhen (CN); and Jian Xie, Shenzhen (CN)
Assigned to Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen (CN)
Filed by Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen (CN)
Filed on Jun. 21, 2021, as Appl. No. 17/353,532.
Application 17/353,532 is a continuation of application No. PCT/CN2018/123529, filed on Dec. 25, 2018.
Prior Publication US 2021/0311080 A1, Oct. 7, 2021
Int. Cl. G01N 1/30 (2006.01); G01N 33/96 (2006.01)

CPC G01N 33/96 (2013.01) [G01N 1/30 (2013.01); G01N 2001/305 (2013.01)]

17 Claims

1. A method for preparing erythrocyte simulating particles, the method comprising:

performing oxidization and fixation treatments on erythrocytes by using an erythrocyte treatment solution that has a pH of 5.0-9.0 and an osmotic pressure of 300-800 Osm/kg·H₂O, wherein the erythrocyte treatment solution contains at least one oxidization agent selected from the group consisting of halogen oxygen acid salts and at least one fixation agent selected from the group consisting of aldehydes or acids; and

washing the erythrocytes treated by the erythrocyte treatment solution and suspending the same in a preservation solution,

wherein the at least one oxidization agent has a concentration of 0.01-20 g/L in the erythrocyte treatment solution.