US 12,332,254 B2
Systems, compositions, and methods for evaluating biomechanical properties of cells
Nicholas Abbott, Ithaca, NY (US); and Karthik Nayani, Ithaca, NY (US)
Assigned to CORNELL UNIVERSITY, Ithaca, NY (US)
Appl. No. 17/605,792
Filed by CORNELL UNIVERSITY, Ithaca, NY (US)
PCT Filed Apr. 24, 2020, PCT No. PCT/US2020/029738
§ 371(c)(1), (2) Date Oct. 22, 2021,
PCT Pub. No. WO2020/219825, PCT Pub. Date Oct. 29, 2020.
Claims priority of provisional application 62/837,959, filed on Apr. 24, 2019.
Prior Publication US 2022/0206020 A1, Jun. 30, 2022
Int. Cl. G01N 33/80 (2006.01); C09K 19/06 (2006.01); C09K 19/34 (2006.01); C09K 19/38 (2006.01); G01N 1/36 (2006.01); G06T 7/00 (2017.01)
CPC G01N 33/80 (2013.01) [C09K 19/061 (2013.01); C09K 19/3402 (2013.01); C09K 19/3819 (2013.01); G01N 1/36 (2013.01); G06T 7/0012 (2013.01); C09K 2019/3425 (2013.01); G06T 2207/10056 (2013.01); G06T 2207/30024 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A system, comprising:
a liquid crystal material, wherein the liquid crystal material has a first state at a first condition and optionally a second state at a second condition;
a device for holding a cell or an organelle of a cell, and the liquid crystal material, wherein the device is designed for use in optical imaging the cell or the organelle in the presence of the liquid crystal material at an isotonic concentration; and
wherein the system is configured to compare a first state of the cell or the organelle in the first state of the liquid crystal material to a second state of the cell or the organelle at the second state of the liquid crystal material or a second state in an aqueous buffer to determine a biomechanical property of the cell or the organelle.