US 12,332,253 B2
Methods for diagnosing an inflammatory bowel disease based on soluble tumor necrosis factor II (sTNFRII) levels in a patient sample and treating thereafter
Jeff D. Debad, Gaithersburg, MD (US); Eli N. Glezer, Del Mar, CA (US); and Sudeep M. Kumar, Basking Ridge, NJ (US)
Assigned to Meso Scale Technologies, LLC., Rockville, MD (US)
Filed by Meso Scale Technologies, LLC., Rockville, MD (US)
Filed on Apr. 14, 2022, as Appl. No. 17/720,956.
Application 13/775,952 is a division of application No. 12/818,093, filed on Jun. 17, 2010, abandoned.
Application 17/720,956 is a continuation of application No. 16/901,294, filed on Jun. 15, 2020, abandoned.
Application 16/901,294 is a continuation of application No. 15/716,743, filed on Sep. 27, 2017, granted, now 10,712,351, issued on Jul. 14, 2020.
Application 15/716,743 is a continuation of application No. 14/478,221, filed on Sep. 5, 2014, granted, now 9,804,173, issued on Oct. 31, 2017.
Application 14/478,221 is a continuation of application No. 13/775,952, filed on Feb. 25, 2013, abandoned.
Application 12/818,093 is a continuation of application No. 11/301,274, filed on Dec. 9, 2005, abandoned.
Claims priority of provisional application 60/634,590, filed on Dec. 9, 2004.
Prior Publication US 2023/0038393 A1, Feb. 9, 2023
Int. Cl. G01N 33/68 (2006.01)
CPC G01N 33/6893 (2013.01) [G01N 33/6863 (2013.01); G01N 2333/523 (2013.01); G01N 2333/525 (2013.01); G01N 2333/70578 (2013.01); G01N 2800/065 (2013.01); G01N 2800/52 (2013.01)] 22 Claims
 
1. A method for diagnosing an inflammatory bowel disease (IBD) in a patient suspected of having IBD comprising:
a) receiving a comparison of a detection cut-off value of sTNFRII between 5 and 7 ng per ml of sample as determined using a Meso Scale Discovery protocol to a level of sTNFRII in a test sample obtained from said patient;
b) wherein when said sTNFRII level in said test sample is above said detection cut-off value;
c) administering to the patient an effective amount of a drug for treatment of the IBD.