US 12,332,244 B2
Composition for diagnosing diseases associated with COX2 overexpression and screening method therefor
Jae-Sung Bae, Daegu (KR); Hee Kyung Jin, Daegu (KR); and Ju Youn Lee, Daegu (KR)
Assigned to KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Daegu (KR)
Appl. No. 16/972,492
Filed by KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Daegu (KR)
PCT Filed Jun. 4, 2019, PCT No. PCT/KR2019/006751
§ 371(c)(1), (2) Date Dec. 4, 2020,
PCT Pub. No. WO2019/235824, PCT Pub. Date Dec. 12, 2019.
Claims priority of application No. 10-2018-0066312 (KR), filed on Jun. 8, 2018.
Prior Publication US 2021/0270834 A1, Sep. 2, 2021
Int. Cl. G01N 33/573 (2006.01); G01N 33/574 (2006.01); G01N 33/68 (2006.01)
CPC G01N 33/573 (2013.01) [G01N 33/57484 (2013.01); G01N 33/6896 (2013.01); G01N 2333/90274 (2013.01)] 7 Claims
 
1. An analysis method comprising: measuring binding between a compound and a cyclooxygenase 2 (COX2) protein defined by SEQ ID NO: 1 in a sample obtained from a subject, wherein the compound is a compound defined by Chemical Formula 1:

OG Complex Work Unit Chemistry
wherein,
at least one atom of the compound defined by Chemical Formula 1 is a radioactive isotope, R1 is hydrogen or C1-C7 alkylcarbonyl, R2 and R3 are each independently hydrogen, C1-C7 alkylcarbonyl, or

OG Complex Work Unit Chemistry
 and n is an integer of 5 to 15, and wherein at least one of R1, R2, and R3 is a C1-C7 alkylcarbonyl.