US 12,332,223 B2
Apparatus and methods for multidimensional chromatography analysis
Michael Organ, Ottawa (CA); Debasis Mallik, Ottawa (CA); Jee Seong Kwak, Ottawa (CA); and Wenyao Zhang, East Gwillimbury (CA)
Filed by Michael Organ, Ottawa (CA); Debasis Mallik, Ottawa (CA); Jee Seong Kwak, Ottawa (CA); and Wenyao Zhang, East Gwillimbury (CA)
Filed on Jun. 23, 2021, as Appl. No. 17/355,467.
Claims priority of provisional application 63/045,388, filed on Jun. 29, 2020.
Prior Publication US 2021/0404998 A1, Dec. 30, 2021
Int. Cl. G01N 30/30 (2006.01); G01N 30/16 (2006.01); G01N 30/38 (2006.01); G01N 30/86 (2006.01); G01N 30/02 (2006.01)
CPC G01N 30/38 (2013.01) [G01N 30/16 (2013.01); G01N 30/8624 (2013.01); G01N 2030/027 (2013.01); G01N 2030/385 (2013.01)] 27 Claims
OG exemplary drawing
 
1. A multidimensional chromatographic assembly comprising:
a) at least a two-configuration injector module, which receives a sample in a fluid holding compartment (a first) from the first (load) configuration of the injector module and sends the sample to a chromatographic medium selector module from the second (inject) configuration using at least one eluent from a fluid moving module located upstream of the injector module;
b) a chromatographic medium module, which comprises two independent flow-paths consisting of at least one chromatographic medium in each and receives the sample in one of the two flow-paths from the chromatographic medium selector module;
c) a detector module, which receives chromatographed portion(s) of the sample from the chromatographic medium module and measures at least one attribute of the portion(s) in a flow-cell, which is a part of the detector module;
d) a multi-configuration fluid diverting module, which is situated downstream of the chromatographic medium module and upstream of the detector module, and equipped with at least two fluid holding compartments (a second and a third) on the stationary portion of the fluid diverting module (the stator) and at least eight flow-paths on the movable portion of the fluid diverting module (the rotor) for receiving chromatographed portion(s) of the sample from the chromatographic medium module, isolating the portion(s) in either the second or the third fluid holding compartment while moving the remaining portion(s) of the chromatographed sample through one of the two flow-paths of the chromatographic medium module, and sending the isolated portion either to the detector module in an iterative manner or to a collection module downstream of the fluid diverting module; and
e) a controller, which receives data from the detector module and sends instructions to the modules of the multidimensional chromatographic assembly.