US 12,332,198 B2
Metabolite based diagnostics for periprosthetic joint infection
Paul Stoodley, Columbus, OH (US); Rafael Bruschweiler, Columbus, OH (US); and Abigail Leggett, Columbus, OH (US)
Assigned to Ohio State Innovation Foundation, Columbus, OH (US)
Filed by Ohio State Innovation Foundation, Columbus, OH (US)
Filed on Jul. 11, 2023, as Appl. No. 18/350,477.
Claims priority of provisional application 63/359,930, filed on Jul. 11, 2022.
Prior Publication US 2024/0019387 A1, Jan. 18, 2024
Int. Cl. G01N 24/08 (2006.01); A61K 31/132 (2006.01); A61P 31/04 (2006.01)
CPC G01N 24/082 (2013.01) [A61K 31/132 (2013.01); A61P 31/04 (2018.01); G01N 2800/26 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of detecting and identifying at least one metabolite from a joint infection in a subject, the method comprising:
a. aspirating a joint fluid sample from the subject;
b. culturing the joint fluid sample with a bacterium; and
c. measuring the at least one metabolite on a nuclear magnetic resonance (NMR) spectrometer.