US 12,332,160 B2
Apparatus, system, and method for testing biological samples
Carlo Daep, Brooklyn, NY (US); Deon Hines, Piscataway, NJ (US); Harsh Mahendra Trivedi, Hillsborough, NJ (US); James Masters, Ringoes, NJ (US); LaTonya Kilpatrick-Liverman, Princeton, NJ (US); Luciana Rinaudi Marron, Somerset, NJ (US); Lynette Zaidel, Cranford, NJ (US); Alexander H. Rickard, Ann Arbor, MI (US); Derek S. Samarian, Ann Arbor, MI (US); and Gregory Kruse, Ann Arbor, MI (US)
Assigned to COLGATE-PALMOLIVE COMPANY, New York, NY (US)
Appl. No. 17/250,473
Filed by Colgate-Palmolive Company, New York, NY (US); and Regents of the University of Michigan, Ann Arbor, MI (US)
PCT Filed Oct. 29, 2020, PCT No. PCT/US2020/070716
§ 371(c)(1), (2) Date Jan. 27, 2021,
PCT Pub. No. WO2021/092612, PCT Pub. Date May 14, 2021.
Claims priority of provisional application 62/933,021, filed on Nov. 8, 2019.
Prior Publication US 2022/0357268 A1, Nov. 10, 2022
Int. Cl. G01N 21/05 (2006.01); G01N 21/64 (2006.01); G06V 20/69 (2022.01)
CPC G01N 21/05 (2013.01) [G01N 21/6458 (2013.01); G06V 20/69 (2022.01)] 18 Claims
OG exemplary drawing
 
1. A system for testing one or more biological samples, the system comprising: a frame comprising: a first side, a second side, a third side, a fourth side, the third side having a first longitudinal passageway and the fourth side having a second longitudinal passageway, the first and second longitudinal passageways configured as fluid conduits, the frame comprising no other fluid conduits other than the first and second longitudinal passageways, the first side, the second side, the third side, and the fourth side forming an outer surface of the frame, and an aperture extending from the first side to the second side, the first and second longitudinal passageways extending through the frame to the aperture; a first cover attached to the first side and covering the aperture; a second cover attached to the second side and covering the aperture;
at least one well formed by a space enclosed by the first cover, the second, and the aperture; and an electromagnetic imaging device configured to image the one or more biological samples through at least one of: the first cover, or the second cover; wherein the first and second covers form a fluid tight and leak-free joint with the frame such that no fluid escapes from the at least one well except via the first and second longitudinal passageways; and wherein a depth of the well as defined by a distance between the first cover and the second cover is greater than a diameter of the first longitudinal passageway.