US 12,331,427 B2
Antibodies that bind GLP1R
Ray Tabibiazar, Chattanooga, TN (US); Aaron Sato, Burlingame, CA (US); Pankaj Garg, Burlingame, CA (US); Qiang Liu, Palo Alto, CA (US); and Fumiko Axelrod, Palo Alto, CA (US)
Assigned to Twist Bioscience Corporation, South San Francisco, CA (US)
Filed by Twist Bioscience Corporation, South San Francisco, CA (US)
Filed on Sep. 30, 2022, as Appl. No. 17/937,377.
Application 17/937,377 is a division of application No. 16/802,423, filed on Feb. 26, 2020, granted, now 11,492,727.
Claims priority of provisional application 62/961,104, filed on Jan. 14, 2020.
Claims priority of provisional application 62/945,049, filed on Dec. 6, 2019.
Claims priority of provisional application 62/904,563, filed on Sep. 23, 2019.
Claims priority of provisional application 62/855,836, filed on May 31, 2019.
Claims priority of provisional application 62/830,316, filed on Apr. 5, 2019.
Claims priority of provisional application 62/810,377, filed on Feb. 26, 2019.
Prior Publication US 2023/0193513 A1, Jun. 22, 2023
Int. Cl. C40B 40/10 (2006.01); C07K 16/28 (2006.01); C40B 40/08 (2006.01)
CPC C40B 40/08 (2013.01) [C07K 16/2869 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/54 (2013.01); C07K 2317/55 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/624 (2013.01); C07K 2317/92 (2013.01)] 12 Claims
OG exemplary drawing
 
1. An antibody or antibody fragment that binds GLP1R, wherein the antibody or antibody fragment comprises a heavy chain comprising a heavy chain variable region (VH) and a light chain comprising a light chain variable region (VL), wherein:
(a) the heavy chain comprises the amino acid sequence of residues 20 to 504 of SEQ ID NO: 2305 and the light chain comprises the amino acid sequence of residues 21 to 236 of SEQ ID NO: 2312;
(b) the heavy chain comprises the amino acid sequence of residues 20 to 507 of SEQ ID NO: 2306 and the light chain comprises the amino acid sequence of residues 21 to 236 of SEQ ID NO: 2313;
(c) the heavy chain comprises the amino acid sequence of residues 20 to 504 of SEQ ID NO: 2307 and the light chain comprises the amino acid sequence of residues 21 to 235 of SEQ ID NO: 2314; or
(d) the heavy chain comprises the amino acid sequence of residues 20 to 494 of SEQ ID NO: 2309 and the light chain comprises the amino acid sequence of residues 21 to 236 of SEQ ID NO: 2316.