	US 12,331,355 B2
	Oligonucleotide conjugate with high hybridization performance and use thereof
Xiwen Jiang, Guangdong (CN); Ling He, Guangdong (CN); and Shilong Lan, Guangdong (CN)
Assigned to Daan Gene Co., Ltd., Guangdong (CN)
Appl. No. 16/957,240
Filed by Daan Gene Co., Ltd., Guangdong (CN)
PCT Filed Apr. 21, 2020, PCT No. PCT/CN2020/085956 § 371(c)(1), (2) Date Jun. 23, 2020, PCT Pub. No. WO2021/189574, PCT Pub. Date Sep. 30, 2021.
Claims priority of application No. 202010227318.9 (CN), filed on Mar. 27, 2020.
Prior Publication US 2022/0333155 A1, Oct. 20, 2022
Int. Cl. C12Q 1/6876 (2018.01); C12Q 1/6851 (2018.01); A61K 51/04 (2006.01)

CPC C12Q 1/6876 (2013.01) [C12Q 1/6851 (2013.01); A61K 51/0406 (2013.01)]

14 Claims

1. An oligonucleotide conjugate, wherein the structure of the oligonucleotide conjugate is shown in the following Formula I:

R—N-Q-D, I

wherein R is an optional fluorescent group, N is an oligonucleotide unit, Q is a quenching group, and D is a cationic unit.