CPC C12N 5/0693 (2013.01) [A61K 40/22 (2025.01); A61K 40/35 (2025.01); A61K 40/4201 (2025.01); C12N 5/10 (2013.01); C12N 15/63 (2013.01); A61K 2039/5152 (2013.01); C12N 2502/99 (2013.01)] | 15 Claims |
1. A vaccine, comprising:
a non-apoptotic senescent or mitosis-arrested irradiated cell which expresses a target antigen,
wherein the cell has been genetically edited to:
express a serpin protease inhibitor;
knockout CD47;
knockout PD-L1; and
genomically integrate a gene encoding GM-CSF.
|