	US 12,331,230 B2
	Protein-based adhesive and its modification
Julie C. Liu, West Lafayette, IN (US); Sydney E. Hollingshead, Cleveland, OH (US); Charng-Yu Lin, West Lafayette, IN (US); and Jonathan J. Wilker, West Lafayette, IN (US)
Assigned to Purdue Research Foundation
Appl. No. 17/270,095
Filed by Purdue Research Foundation, West Lafayette, IN (US)
PCT Filed Aug. 22, 2019, PCT No. PCT/US2019/047639 § 371(c)(1), (2) Date Feb. 22, 2021, PCT Pub. No. WO2020/041557, PCT Pub. Date Feb. 27, 2020.
Claims priority of provisional application 62/721,112, filed on Aug. 22, 2018.
Prior Publication US 2021/0207013 A1, Jul. 8, 2021
Int. Cl. C09J 189/00 (2006.01); A61L 24/10 (2006.01); C07K 14/78 (2006.01); C09J 11/04 (2006.01)

CPC C09J 189/00 (2013.01) [A61L 24/108 (2013.01); C07K 14/78 (2013.01); C09J 11/04 (2013.01)]

4 Claims

1. An adhesive comprising (i) a crosslinking agent selected from tetrakis(hydroxymethyl)phosphonium chloride (THPC), an N-hydroxysuccinyl ester (NHS), genipin, pyridyl disulfide, a maleimide, a vinylsulfone, a haloacetyl, and a combination thereof, (ii) an elastin-like polypeptide (ELP), wherein polypeptide chain of said ELP comprises (a) a tyrosine residue, a derivative thereof, or a combination thereof and (b) at least one of a lysine residue, a cysteine residue, or a combination thereof, and (iii) an oxidizing agent selected from a ferric salt, a hydrogen peroxide, and a sodium periodate, wherein the ELP comprises at least one of SEQ ID NOs: 4, 6, 8 or 10.