US 12,331,106 B2
Anti-angiopoietin-2 antibodies that induce Tie2 activation
Gou Young Koh, Daejeon (KR); Jeomil Bae, Daejeon (KR); Mi Jeong Kim, Daejeon (KR); Jin-Sung Park, Daejeon (KR); Su Jin Seo, Daejeon (KR); Jaeryung Kim, Daejeon (KR); Jang Ryul Park, Daejeon (KR); Pilhan Kim, Daejeon (KR); and Wangyuhl Oh, Daejeon (KR)
Assigned to Institute for Basic Science, Daejeon (KR); and Korea Advanced Instritute of Science and Technology, Daejeon (KR)
Filed by Institute for Basic Science, Daejeon (KR); and Korea Advanced Institute of Science and Technology, Daejeon (KR)
Filed on Oct. 12, 2022, as Appl. No. 18/045,964.
Application 18/045,964 is a division of application No. 16/995,707, filed on Aug. 17, 2020, granted, now 11,498,962.
Application 16/995,707 is a continuation of application No. PCT/KR2019/001983, filed on Feb. 19, 2019.
Claims priority of provisional application 62/633,038, filed on Feb. 20, 2018.
Claims priority of application No. 10-2019-0018769 (KR), filed on Feb. 18, 2019.
Prior Publication US 2023/0272057 A1, Aug. 31, 2023
Int. Cl. C07K 16/22 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/22 (2013.01) [A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01)] 11 Claims
 
1. An antibody or antigen-binding fragment thereof that specifically binds human Angiopoietin-2 and induces Tie2 activation, wherein the antibody or antigen-binding fragment thereof comprises:
(a) the complementarity determining regions (CDRs) of a heavy chain variable region comprising HCDR1 amino acid sequence of SEQ ID NO: 3, the HCDR2 amino acid sequence of SEQ ID NO: 4, and the HCDR3 amino acid sequence of SEQ ID NO: 5; and
(b) the CDRs of a light chain variable region comprising the LCDR1 amino acid sequence of SEQ ID NO: 6, the LCDR2 amino acid sequence of SEQ ID NO: 7, and the LCDR3 amino acid sequence of SEQ ID NO: 8.