	US 12,331,103 B2
	Fibronectin binding domain chimeric antigen receptors and methods of use thereof
Roberto Crea, Burlingame, CA (US); Jun Yoon, Burlingame, CA (US); Craig A. Hokanson, Pleasanton, CA (US); and Emanuela Zacco, Burlingame, CA (US)
Assigned to PROTELICA, INC., Burlingame, CA (US)
Appl. No. 16/623,225
Filed by PROTELICA, INC., Burlingame, CA (US)
PCT Filed Jun. 15, 2018, PCT No. PCT/US2018/037945 § 371(c)(1), (2) Date Dec. 16, 2019, PCT Pub. No. WO2018/232372, PCT Pub. Date Dec. 20, 2018.
Claims priority of provisional application 62/521,095, filed on Jun. 16, 2017.
Prior Publication US 2022/0002384 A1, Jan. 6, 2022
Int. Cl. C07K 14/78 (2006.01); A61K 38/00 (2006.01); A61K 40/31 (2025.01); C07K 14/705 (2006.01)

CPC C07K 14/78 (2013.01) [A61K 40/31 (2025.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); A61K 38/00 (2013.01); C07K 2317/31 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/21 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C07K 2319/70 (2013.01)]

5 Claims

1. A chimeric antigen receptor (CAR) comprising:

i) at least one antigen specific targeting region comprising a fibronectin type 3 (FN3) domain polypeptide;

ii) a transmembrane domain; and

iii) an intracellular signaling domain,

wherein the CAR further comprises an extracellular spacer domain

wherein the least one antigen specific targeting region comprises an amino acid sequence set forth in SEQ ID NO: 33.