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1. A recombinant nucleic acid encoding a T cell receptor (TCR) comprising a TCR beta chain construct comprising a beta chain complementarity determining region 1 (CDR1), a beta chain complementarity determining region 2 (CDR2), and a beta chain complementarity determining region 3 (CDR3); and a TCR alpha chain construct comprising an alpha chain CDR1, an alpha chain CDR2, and an alpha chain CDR3, wherein the beta chain CDR1 has an amino acid sequence set forth in SEQ ID NO: 50; the beta chain CDR2 has an amino acid sequence set forth in SEQ ID NO: 51; the beta chain CDR3 has an amino acid sequence as set forth in SEQ ID NO: 52; the alpha chain CDR1 has an amino acid sequence as set forth in SEQ ID NO: 47; the alpha chain CDR2 has an amino acid sequence as set forth in SEQ ID NO: 48; and the alpha chain CDR3 has an amino acid sequence as set forth in SEQ ID NO: 49, wherein the TCR specifically binds to a mutated RAS epitope in complex with a human MHC encoded by an HLA-A11:01 allele, wherein the mutated RAS epitope has a sequence set forth in SEQ ID NOs: 45 or 46, and wherein the recombinant nucleic acid is comprised in a vector.
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