	US 12,331,091 B2
	Chimeric signal peptides for protein production
Chao-Yi Teng, Taipei (TW); and Ying-Ju Chen, Taipei (TW)
Assigned to Taiwan Bio-Manufacturing Corporation, Taipei (TW)
Appl. No. 17/417,112
Filed by Taiwan Bio-Manufacturing Corporation, Taipei (TW)
PCT Filed Dec. 23, 2019, PCT No. PCT/US2019/068406 § 371(c)(1), (2) Date Jun. 22, 2021, PCT Pub. No. WO2020/139855, PCT Pub. Date Jul. 2, 2020.
Claims priority of provisional application 62/784,497, filed on Dec. 23, 2018.
Prior Publication US 2021/0388046 A1, Dec. 16, 2021
Int. Cl. C07K 14/00 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C12N 9/16 (2006.01)

CPC C07K 14/4728 (2013.01) [C07K 14/4723 (2013.01); C07K 14/70503 (2013.01); C07K 16/00 (2013.01); C12N 9/16 (2013.01); C12Y 301/03001 (2013.01); C07K 2317/14 (2013.01); C07K 2319/02 (2013.01)]

2 Claims

1. A chimeric signal peptide for protein expression, comprising an N-region, a hydrophobic region (H-region), and a C-region, wherein the N-region and the C-region are from a signal peptide of a first protein and the hydrophobic region (H-region) is from a signal peptide of a second protein, wherein the first protein is BM40 and the second protein is CD33.