	US 12,331,087 B2
	Human anti-ANTXR chimeric antigen receptor and use thereof
Kyung-Mi Lee, Seoul (KR); Seung-Hyun Jeon, Seoul (KR); Baeckseung Lee, Seoul (KR); Yoon Lee, Gyeonggi-do (KR); and Young-Kwan Lee, Seoul (KR)
Assigned to MJCELL BIO CO., LTD., Gyeonggi-Do (KR)
Appl. No. 17/311,619
Filed by MJCELL BIO CO., LTD., Gyeonggi-do (KR)
PCT Filed Dec. 6, 2019, PCT No. PCT/KR2019/017215 § 371(c)(1), (2) Date Jun. 7, 2021, PCT Pub. No. WO2020/117004, PCT Pub. Date Jun. 11, 2020.
Prior Publication US 2022/0372084 A1, Nov. 24, 2022
Int. Cl. C07K 14/32 (2006.01); A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/42 (2025.01); A61P 1/18 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01)

CPC C07K 14/32 (2013.01) [A61K 40/11 (2025.01); A61K 40/31 (2025.01); A61K 40/4202 (2025.01); A61K 40/4269 (2025.01); A61P 1/18 (2018.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/54 (2023.05); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01)]

16 Claims

1. A nucleic acid encoding a chimeric antigen receptor (CAR) comprising an extracellular binding domain, a transmembrane domain, and an intracellular signaling domain, wherein the extracellular binding domain is domain 4 (D4) of a PA63 ligand or a fragment comprising domain 4 (D4) and domain 3 (D3) of a PA63 ligand, and recognizes an anthrax toxin receptor (ANTXR).