US 12,331,067 B2
Method for preparing 18F-BPA and intermediate
Shi-hong Li, Jiangsu (CN); Jing He, Jiangsu (CN); Heng Yan, Jiangsu (CN); and Fei Cai, Jiangsu (CN)
Assigned to NEUBORON MEDTECH LTD., Jiangsu (CN)
Filed by NEUBORON MEDTECH LTD., Jiangsu (CN)
Filed on Apr. 10, 2023, as Appl. No. 18/132,479.
Application 18/132,479 is a continuation of application No. 17/171,224, filed on Feb. 9, 2021, granted, now 11,655,261.
Application 17/171,224 is a continuation of application No. PCT/CN2019/100678, filed on Aug. 15, 2019.
Claims priority of application No. 201810940708.3 (CN), filed on Aug. 17, 2018; application No. 201811478614.5 (CN), filed on Dec. 5, 2018; and application No. 201811478615.X (CN), filed on Dec. 5, 2018.
Prior Publication US 2023/0242555 A1, Aug. 3, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 229/34 (2006.01); C07B 59/00 (2006.01); C07C 249/02 (2006.01); C07F 5/02 (2006.01)
CPC C07F 5/027 (2013.01) [C07B 59/004 (2013.01); C07C 229/34 (2013.01); C07C 249/02 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An intermediate I of the structure

OG Complex Work Unit Chemistry
where R1 represents boric acid groups or substituents that is hydrolyzable to boric acid groups;
R2 represents boric acid groups or substituents that is hydrolyzable to boric acid groups;
R3 represents hydrogen, an amino-protecting group, or an imino group combined with an amino group for protecting the amino group;
R4 represents hydrogen, an amino-protecting group, or an imino group combined with an amino group for protecting the amino group; and
R5 represents hydrogen or a carboxyl-protecting group.