US 12,331,059 B2
Class of functional molecules targeting proteolysis pathways, preparation and application thereof
Chongjing Zhang, Beijing (CN); Fujia Wang, Beijing (CN); Zi Ye, Beijing (CN); Wanqi Yang, Beijing (CN); and Ke Li, Beijing (CN)
Assigned to Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing (CN)
Appl. No. 17/641,485
Filed by Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing (CN)
PCT Filed Sep. 9, 2020, PCT No. PCT/CN2020/114125
§ 371(c)(1), (2) Date Mar. 9, 2022,
PCT Pub. No. WO2021/047524, PCT Pub. Date Mar. 18, 2021.
Claims priority of application No. 201910848612.9 (CN), filed on Sep. 9, 2019.
Prior Publication US 2022/0380381 A1, Dec. 1, 2022
Int. Cl. C07D 493/18 (2006.01); A61P 35/02 (2006.01); C07D 417/14 (2006.01)
CPC C07D 493/18 (2013.01) [A61P 35/02 (2018.01); C07D 417/14 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A compound of formula (M)

OG Complex Work Unit Chemistry
Wherein:
R″ is

OG Complex Work Unit Chemistry
L is —C1-C8 alkylene, oxygen-containing alkylene, or

OG Complex Work Unit Chemistry
the number of oxygen atoms in said oxygen-containing alkylene is 1, 2, 3, 4 or 5, said oxygen is connected with C2 alkylene;
when R″ is R3, n is independently selected from 0, 1, 2, 3, 4 or 5; X is oxygen or —CH2—,
or a pharmaceutical acceptable salt or stereoisomer thereof.