	US 12,331,030 B2
	Piperidine-2,6-dione derivatives and ulcerative colitis treating
Hesheng Zhang, Tianjin (CN); and Guanghuai Zeng, Tianjin (CN)
Assigned to Tianjin Hemay Pharmaceutical Sci-Tech Co., Ltd, Tianjin (CN); and Ganzhou Hemay Pharmaceutical, Co., Ltd, Ganzhou (CN)
Filed by TIANJIN HEMAY PHARMACEUTICAL SCI-TECH CO., LTD, Tianjin (CN); and GANZHOU HEMAY PHARMACEUTICAL, CO., LTD, Ganzhou (CN)
Filed on Dec. 8, 2023, as Appl. No. 18/533,755.
Application 17/832,518 is a division of application No. 16/464,224, granted, now 11,485,724, issued on Nov. 1, 2022, previously published as PCT/CN2017/112668, filed on Nov. 23, 2017.
Application 18/533,755 is a continuation of application No. 17/832,518, filed on Jun. 3, 2022, granted, now 11,873,287.
Claims priority of application No. 201611041317.5 (CN), filed on Nov. 24, 2016.
Prior Publication US 2024/0132466 A1, Apr. 25, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/04 (2006.01); A61K 9/08 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01)

CPC C07D 401/04 (2013.01) [A61P 1/00 (2018.01); A61P 1/04 (2018.01); A61K 9/08 (2013.01); A61K 9/2018 (2013.01); A61K 9/4891 (2013.01)]

30 Claims

1. A method for treating ulcerative colitis, comprising administering a therapeutically effective amount of a piperidine-2,6-dione derivative or pharmaceutically acceptable salts thereof to a subject in need thereof, the piperidine-2,6-dione derivative being selected from the group consisting of:

4-acetylamino-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-methylamino-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-dimethylamino-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-fluoro-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4,5,6,7-tetrafluoro-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-amino-2-(1-(2-hydroxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

5-amino-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-amino-5-hydroxy-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof,

4-amino-5-fluoro-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof,

4-amino-7-hydroxy-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-acetylamino-2-(1-(3-methoxypropyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-fluoro-2-(1-(3-methoxypropyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

5-amino-2-(1-(3-methoxypropyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-amino-2-(1-(2-ethoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione pharmaceutically acceptable salts thereof; and

4-fluoro-2-(1-(2-ethoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

5-fluoro-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl)-isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-amino-2-(1-(4-methoxybutyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-hydroxy-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-methyl-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl)-isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-amino-5-methoxy-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl)-isoindolin-1,3-dione and pharmaceutically acceptable salts thereof;

4-amino-2-(1-(3-methoxypropyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof; and

4-amino-2-(1-(2-methoxyethyl)-2,6-dioxopiperidin-3-yl) isoindolin-1,3-dione and pharmaceutically acceptable salts thereof.