US 12,330,127 B2
Aqueous systems of at least two phases containing microcapsules and processes for manufacturing the same
Daeyeon Lee, Wynnewood, PA (US); Kathleen J Stebe, Penn Valley, PA (US); and Sarah D Hann, Yardley, PA (US)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed by The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed on Nov. 30, 2021, as Appl. No. 17/537,840.
Application 17/537,840 is a continuation of application No. 15/952,321, filed on Apr. 13, 2018, granted, now 11,260,358.
Claims priority of provisional application 62/486,154, filed on Apr. 17, 2017.
Prior Publication US 2022/0088556 A1, Mar. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. B01J 13/10 (2006.01); A61K 9/50 (2006.01); A61K 35/74 (2015.01); B01J 13/04 (2006.01); C12N 11/04 (2006.01); C12N 11/082 (2020.01); C12N 11/087 (2020.01); C12N 11/089 (2020.01); C12N 11/098 (2020.01); C12N 11/10 (2006.01); A61K 35/12 (2015.01)
CPC B01J 13/10 (2013.01) [A61K 9/5031 (2013.01); A61K 9/5036 (2013.01); A61K 35/74 (2013.01); B01J 13/04 (2013.01); C12N 11/04 (2013.01); C12N 11/082 (2020.01); C12N 11/087 (2020.01); C12N 11/089 (2020.01); C12N 11/098 (2020.01); C12N 11/10 (2013.01); A61K 2035/128 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A process for forming microcapsules in an aqueous dispersion, comprising:
injecting (1) a dispersed phase that includes at least a first component and a first hydrophilic compound into (2) a continuous phase that includes at least a second component and a second hydrophilic compound,
the first component and the second component being mutually attractive, such that a film is formed by complexation of the first component and the second component, and
wherein (a) one of the first component and the second component is a nanoparticle and the other of the first component and the second component comprises a charged electrolyte or a polyelectrolyte, (b) one of the first hydrophilic compound and the second hydrophilic compound comprises polyethylene glycol (PEG), or both (a) and (b).