US 12,329,990 B2
Matched filter in ionoacoustic signal processing for ion beam range determination and dosimetry
Jannis Schauer, Munich (DE); Günther Dollinger, Garching (DE); Heinrich Ruser, Munich (DE); Yuanhui Huang, Eching (DE); Vasilis Ntziachristos, Munich (DE); Hans Peter Wieser, Munich (DE); and Katia Parodi, Munich (DE)
Assigned to Universität der Bundeswehr München, Neubiberg (DE); Technische Universität München, Munich (DE); and Ludwig-Maximilians-Universität München, Munich (DE)
Filed by Universität der Bundeswehr München, Neubiberg (DE); Technische Universität München, Munich (DE); and Ludwig-Maximilians-Universität München, Munich (DE)
Filed on Feb. 28, 2023, as Appl. No. 18/176,047.
Claims priority of application No. 22159975 (EP), filed on Mar. 3, 2022.
Prior Publication US 2023/0277875 A1, Sep. 7, 2023
Int. Cl. A61N 5/10 (2006.01); A61B 8/00 (2006.01)
CPC A61N 5/1071 (2013.01) [A61B 8/4488 (2013.01); A61N 2005/1041 (2013.01); A61N 2005/1087 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of determining information regarding a location of energy deposition of an ion beam in an absorptive medium, comprising the following steps:
generating a pulsed ion beam,
detecting a time-resolved acoustic signal, said time-resolved acoustic signal comprising an energy-deposition-signal component attributable to the energy deposition of an individual pulse of said pulsed ion beam in said absorptive medium,
determining relative timing information of the energy deposition of said individual pulse with respect to said time-resolved acoustic signal,
providing a matched filter for processing the time-resolved acoustic signal, said matched filter being configured to facilitate detecting said energy-deposition-signal component within said time-resolved acoustic signal,
applying said matched filter to said time-resolved acoustic signal to thereby obtain a filtered time-resolved signal,
deriving, from said filtered time-resolved signal, occurrence timing information related to an occurrence of said energy-deposition signal component in said time-resolved acoustic signal, and
deriving information regarding the location of the energy deposition based, at least in part, on a delay between said energy deposition of said individual pulse and said occurrence timing information.