US 12,329,967 B2
State-dependent peripheral neuromodulation to treat bladder dysfunction
Warren M. Grill, Chapel Hill, NC (US); James A. Hokanson, Morrisville, NC (US); and Christopher L. Langdale, Apex, NC (US)
Assigned to Duke University, Durham, NC (US)
Filed by Duke University, Durham, NC (US)
Filed on Mar. 1, 2023, as Appl. No. 18/115,905.
Application 18/115,905 is a continuation of application No. 16/897,392, filed on Jun. 10, 2020, granted, now 11,617,886.
Application 16/897,392 is a continuation of application No. 15/767,400, granted, now 10,722,708, previously published as PCT/US2016/057043, filed on Oct. 14, 2016.
Claims priority of provisional application 62/241,825, filed on Oct. 15, 2015.
Prior Publication US 2023/0211158 A1, Jul. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01); A61K 45/06 (2006.01); A61N 1/372 (2006.01)
CPC A61N 1/36007 (2013.01) [A61N 1/36196 (2013.01); A61K 45/06 (2013.01); A61N 1/0556 (2013.01); A61N 1/37235 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A neuromodulation apparatus for stimulating neural activity in a pudendal nerve of a subject, wherein the neuromodulation apparatus applies phase-specific electrical stimulation of the pudendal nerve or subcomponents of the pudendal nerve in response to one or more control signals,
wherein the one or more control signals is provided in response to output of one or more detector elements, and
wherein the one or more detector elements is responsive to a physiological parameter selected from nerve activity in the pudendal nerve, nerve activity in a hypogastric nerve, nerve activity in a pelvic nerve, muscle activity in a bladder detrusor muscle, muscle activity in an internal urethral sphincter, muscle activity in an external urethral sphincter, muscle activity in an external anal sphincter, and bladder pressure, and
wherein the phase-specific electrical stimulation is applied differently depending on whether the physiological parameter indicates a filling phase or a voiding phase of a bladder activity cycle.