US 12,329,883 B2
Soft tissue repair implants comprising hydroxybutyrate
Peter Maughan Crapo, North Kingstown, RI (US); Devang Vijay Shah, Franklin, MA (US); Stephen F. Badylak, Pittsburgh, PA (US); George Hussey, Cranberry Township, PA (US); Catalina Pineda Molina, Pittsburgh, PA (US); and Brian Sicari, Pittsburgh, PA (US)
Assigned to Davol Inc., Warwick, RI (US); and University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Appl. No. 16/755,219
Filed by Davol Inc., Warwick, RI (US); and University of Pittsburgh—of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
PCT Filed Oct. 24, 2018, PCT No. PCT/US2018/057199
§ 371(c)(1), (2) Date Apr. 10, 2020,
PCT Pub. No. WO2019/084073, PCT Pub. Date May 2, 2019.
Claims priority of provisional application 62/576,403, filed on Oct. 24, 2017.
Prior Publication US 2020/0261624 A1, Aug. 20, 2020
Int. Cl. A61L 27/54 (2006.01); A61K 31/191 (2006.01); A61L 27/56 (2006.01); A61L 27/58 (2006.01)
CPC A61L 27/54 (2013.01) [A61K 31/191 (2013.01); A61L 27/56 (2013.01); A61L 27/58 (2013.01); A61L 2300/21 (2013.01); A61L 2300/404 (2013.01); A61L 2430/30 (2013.01); A61L 2430/34 (2013.01)] 19 Claims
 
1. A soft tissue repair implant, comprising:
a polymeric material;
a body portion comprising the polymeric material, wherein the body portion is in the form of a three-dimensional shape, a planar shape, or a combination of a three-dimensional shape and a planar shape, and
at least one of a hydroxybutyrate and a conjugate acid of a hydroxybutyrate in a therapeutically-effective amount for reducing or preventing microbial infection, wherein the at least one of a hydroxybutyrate and a conjugate acid of a hydroxybutyrate is part of the body portion and/or is a component of a coating disposed on the body portion,
wherein the soft tissue repair implant is configured to repair a soft tissue defect, and
wherein the at least one of the hydroxybutyrate or the conjugate acid of the hydroxybutyrate is a monomer that is not covalently bonded to any other species.