US 12,329,882 B2
Aligned hydrogel tubes for tissue repair and regeneration
Courtney M. Dumont, Ypsilanti, MI (US); Mitchell A. Carlson, Ann Arbor, MI (US); and Lonnie D. Shea, Ann Arbor, MI (US)
Assigned to REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
Appl. No. 17/050,876
Filed by REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
PCT Filed Apr. 26, 2019, PCT No. PCT/US2019/029407
§ 371(c)(1), (2) Date Oct. 27, 2020,
PCT Pub. No. WO2019/210209, PCT Pub. Date Oct. 31, 2019.
Claims priority of provisional application 62/663,608, filed on Apr. 27, 2018.
Prior Publication US 2021/0322647 A1, Oct. 21, 2021
Int. Cl. A61L 27/52 (2006.01); A61L 27/18 (2006.01); A61L 27/56 (2006.01)
CPC A61L 27/52 (2013.01) [A61L 27/18 (2013.01); A61L 27/56 (2013.01); A61L 2430/32 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of regenerating tissue, the method comprising:
implanting in an injury site an implant comprising two or more porous hydrogel tubes wherein the hydrogel tubes each comprise a plurality of crosslinked hydrogel particles comprising a polyethylene glycol-based material, wherein the polyethylene glycol-based material comprises polyethylene glycol having one or more reactive side arms, and wherein the crosslinked polyethylene glycol-based hydrogel particles are cross-linked to each other in the form of a tube, and
wherein the hydrogel tubes are aligned and stacked within the injury site.