US 12,329,877 B2
Surgical glues based on monomers comprising a phosphate function
Bertrand Perrin, Dijon (FR); Ariane Aubin, Mulhouse (FR); Jacques Lalevee, Mulhouse (FR); and Jean-Philippe Schwebelen, Burnhaupt-le-Haut (FR)
Appl. No. 17/431,285
Filed by COHESIVES, Dijon (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); and UNIVERSITE DE HAUTE ALSACE, Mulhouse (FR)
PCT Filed Feb. 19, 2020, PCT No. PCT/EP2020/054387
§ 371(c)(1), (2) Date Aug. 16, 2021,
PCT Pub. No. WO2020/169681, PCT Pub. Date Aug. 27, 2020.
Claims priority of application No. 1901771 (FR), filed on Feb. 21, 2019.
Prior Publication US 2022/0125988 A1, Apr. 28, 2022
Int. Cl. A61L 24/04 (2006.01); C08F 22/20 (2006.01)
CPC A61L 24/043 (2013.01) [C08F 22/20 (2013.01); A61L 2300/802 (2013.01); A61L 2400/04 (2013.01); C08F 2810/20 (2013.01)] 14 Claims
 
1. A composition for use as a surgical adhesive for the adhesion of a material to a non-mineralised biological tissue, for the adhesion of non-mineralised biological tissues to one another, for the adhesion of a glue or a substance to the surface of a non-mineralised biological tissue, as surgical sealant, for blocking or plugging orifices created by a thread suture or staple or by a tissue resection, for blocking an orifice, an incision or a tear in a non-mineralised biological tissue, as a haemostatic for stopping bleeding, as a dressing on a non-mineralised biological tissue for covering and protecting a wound, for reinforcing a non-mineralised biological tissue, or for fixing and stabilising a non-mineralised biological tissue, wherein said composition comprises between 10 and 60% by mass relative to the total mass of the composition of a polymerisable monomer comprising a phosphate function or a phosphonate function and a methacrylate function;
wherein the composition comprises a polymerisable monomer of formula I:

OG Complex Work Unit Chemistry
wherein:
R2 is H or CH3;
R1, R1′, and R1″ are independently of one another a linear polyether radical, a linear or branched aliphatic radical with C1-C50, an aromatic radical of C6-C18, for which the carbon chain of said radicals can be interrupted by O, S, OCONH and/or can comprise one or more alcohol functions;
R1′ is H if c=0;
R1″ is H if a=0;
b is 1; and
a or c is 1 or 0.