US 12,329,876 B2
Porous bioresorbable radiopaque embolic microspheres for drug delivery
Durgadas Bolikal, San Diego, CA (US); Lioubov Kabalnova, San Diego, CA (US); Ruth Sosa, San Diego, CA (US); Ernest G. Baluca, San Diego, CA (US); Jessica Earley, San Diego, CA (US); Joann Yao, San Diego, CA (US); and Elizabeth Nesseler, San Diego, CA (US)
Assigned to REVA Medical, LLC, San Diego, CA (US)
Appl. No. 17/272,607
Filed by REVA Medical, LLC, San Diego, CA (US)
PCT Filed Sep. 18, 2019, PCT No. PCT/US2019/051753
§ 371(c)(1), (2) Date Mar. 1, 2021,
PCT Pub. No. WO2020/061207, PCT Pub. Date Mar. 26, 2020.
Claims priority of provisional application 62/734,067, filed on Sep. 20, 2018.
Claims priority of provisional application 62/767,293, filed on Nov. 14, 2018.
Prior Publication US 2022/0001073 A1, Jan. 6, 2022
Int. Cl. A61K 31/337 (2006.01); A61K 31/704 (2006.01); A61L 24/00 (2006.01); A61L 24/06 (2006.01)
CPC A61L 24/001 (2013.01) [A61K 31/337 (2013.01); A61K 31/704 (2013.01); A61L 24/0015 (2013.01); A61L 24/0036 (2013.01); A61L 24/06 (2013.01); A61L 2300/216 (2013.01); A61L 2300/232 (2013.01); A61L 2300/62 (2013.01); A61L 2430/36 (2013.01)] 17 Claims
 
1. Embolic spherical microparticles, comprising:
a copolymer material having at least one radiopaque iodine-containing component and at least one rubbery component;
wherein the rubbery component comprises oligomers or macromers of PEG (polyethylene glycol), PCL (polycaprolactone), PTMO poly(tetramethylene oxide), PTMC poly(trimethylene carbonate) or combinations thereof, and the rubbery component has a Tg below about 37° C.;
wherein the radiopaque iodine-containing component comprises iodinated phenyl-containing monomers, oligomers, or macromers,
wherein the at least one radiopaque iodine-containing component and the at least one rubbery component are connected by two or more different types of chemical bonds comprising fast degrading and slow degrading chemical bonds with different affinities to hydrolysis such that the different chemical bonds have different rates of in vivo hydrolytic degradation, and one type of chemical bonds is oxalate bond, and
wherein the microparticles have internal and/or external porosity formed by the decomposition of fast degrading oxalate bonds.