US 12,329,823 B2
Long-acting dual GIP/GLP-1 peptide conjugates and methods of use
Weijun Shen, Shenzhen (CN); Zaid Amso, El Cajon, CA (US); and Peter G. Schultz, La Jolla, CA (US)
Assigned to THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US)
Filed by The Scripps Research Institute, La Jolla, CA (US)
Filed on Aug. 7, 2023, as Appl. No. 18/366,653.
Application 18/366,653 is a continuation of application No. PCT/CN2022/097662, filed on Jun. 8, 2022.
Claims priority of provisional application 63/208,952, filed on Jun. 9, 2021.
Prior Publication US 2024/0148884 A1, May 9, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/64 (2017.01); A61K 47/54 (2017.01); A61K 47/59 (2017.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01)
CPC A61K 47/64 (2017.08) [A61K 47/542 (2017.08); A61K 47/595 (2017.08); A61P 3/04 (2018.01); A61P 3/10 (2018.01)] 8 Claims
 
1. A peptide conjugate comprising a staple, and a peptide comprising YAibEGTFTSDYSIYLDKCAAAibEFVCWLIAGGPSSGAPPPS (SEQ ID NO: 61), wherein the staple is

OG Complex Work Unit Chemistry
wherein n is 1-4;
m is 6-20;
—S2— is a sulfur atom of the first cysteine of SEQ ID NO:61; and
—S1— is a sulfur atom of the second cysteine of SEQ ID NO:61.