	US 12,329,820 B2
	Cross-linked shear thinning fluid with tunable rheology for 3D bioprinting and drug delivery
Theresa Chang, Painted Post, NY (US); Huayun Deng, Painted Post, NY (US); Benjamin Leonard Linchuck, Charlotte, NC (US); Ying Wei, Painted Post, NY (US); Ying Zhang, Horseheads, NY (US); and Yue Zhou, Horseheads, NY (US)
Assigned to CORNING INCORPORATED, Corning, NY (US)
Appl. No. 16/611,015
Filed by CORNING INCORPORATED, Corning, NY (US)
PCT Filed May 7, 2018, PCT No. PCT/US2018/031290 § 371(c)(1), (2) Date Nov. 5, 2019, PCT Pub. No. WO2018/208632, PCT Pub. Date Nov. 15, 2018.
Claims priority of provisional application 62/505,353, filed on May 12, 2017.
Prior Publication US 2020/0061193 A1, Feb. 27, 2020
Int. Cl. A61K 47/36 (2006.01); A61K 45/06 (2006.01); C08B 37/00 (2006.01)

CPC A61K 47/36 (2013.01) [C08B 37/0045 (2013.01); A61K 45/06 (2013.01)]

19 Claims

1. A shear-thinning fluid comprising: an aqueous solution comprising pectic acid cross-linked by divalent cations, wherein the pectic acid is present in an amount ranging from about 0.5 to about 3.0% (w/v), wherein the divalent cations are present at a concentration of from about 0.5 mM to about 7.0 mM, and wherein the viscosity of the shear-thinning fluid increases with decreasing shear.