US 12,329,773 B2
Oxygen reactive polymers for treatment of traumatic brain injury
Patrick S. Stayton, Seattle, WA (US); Menko P. Ypma, Seattle, WA (US); Peter A. Chiarelli, Seattle, WA (US); Joshua Sang Hun Park, Seattle, WA (US); Richard G. Ellenbogen, Seattle, WA (US); Julia Mengyun Xu, Seattle, WA (US); Pierre D. Mourad, Seattle, WA (US); Donghoon Lee, Seattle, WA (US); Anthony Convertine, Seattle, WA (US); and Forrest M. Kievit, Seattle, WA (US)
Assigned to University of Washington, Seattle, WA (US)
Filed by University of Washington, Seattle, WA (US)
Filed on Jul. 19, 2021, as Appl. No. 17/379,401.
Application 17/379,401 is a continuation of application No. 15/766,314, granted, now 11,065,272, previously published as PCT/US2016/055809, filed on Oct. 6, 2016.
Claims priority of provisional application 62/237,915, filed on Oct. 6, 2015.
Prior Publication US 2022/0152091 A1, May 19, 2022
Int. Cl. A61K 31/765 (2006.01); A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 9/51 (2006.01); A61K 31/795 (2006.01); A61K 47/30 (2006.01); A61P 25/28 (2006.01)
CPC A61K 31/765 (2013.01) [A61K 9/0019 (2013.01); A61K 9/14 (2013.01); A61K 9/51 (2013.01); A61K 31/795 (2013.01); A61K 47/30 (2013.01); A61P 25/28 (2018.01)] 16 Claims
OG exemplary drawing
 
1. A method for treating traumatic brain injury, comprising administering a therapeutically effective amount of a copolymer to a subject in need thereof, wherein the copolymer has the formula

OG Complex Work Unit Chemistry
wherein
n is an integer from 1 to 12,
m is an integer from 0 to 12,
p is an integer from 6 to 40,
R1 and R2 are independently selected from hydrogen or methyl,
a is the mole fraction of the repeating unit and is from about 0.25 to about 0.95,
b is the mole fraction of the polyalkylene oxide containing repeating unit and is from about 0.05 to about 0.75;
a+b is 1.0; and
* represents the remainder of the copolymer.