	US 12,329,759 B2
	Methods and compositions relating to lung function
Elizabeth Jeanne Becker, Cambridge, MA (US); Katrina Steiling, Boston, MA (US); Avrum E. Spira, Newton, MA (US); and Marc E. Lenburg, Brookline, MA (US)
Assigned to TRUSTEES OF BOSTON UNIVERSITY, Boston, MA (US)
Filed by TRUSTEES OF BOSTON UNIVERSITY, Boston, MA (US)
Filed on Oct. 15, 2020, as Appl. No. 17/071,228.
Claims priority of provisional application 62/916,431, filed on Oct. 17, 2019.
Prior Publication US 2021/0113581 A1, Apr. 22, 2021
Int. Cl. A61P 11/08 (2006.01); A61K 9/00 (2006.01); A61K 31/122 (2006.01); A61K 31/135 (2006.01); A61K 31/357 (2006.01); A61K 31/439 (2006.01); A61K 31/55 (2006.01)

CPC A61K 31/55 (2013.01) [A61K 9/0073 (2013.01); A61K 31/122 (2013.01); A61K 31/135 (2013.01); A61K 31/357 (2013.01); A61K 31/439 (2013.01); A61P 11/08 (2018.01)]

29 Claims

1. A method of treating chronic obstructive pulmonary disease (COPD) in a subject in need thereof, the method comprising:

a) determining the level of expression of one or more genes of a first group of genes, the first group of genes consisting of:

surfeit 4 (SURF4); S100 calcium binding protein A16 (S100A16); MIA SH3 domain ER export factor 3 (MIA3); and thioredoxin domain containing 11 (TXNDC11);

in a sample obtained from the subject in need of treatment for COPD; and

i) administering to the subject one or more of:

an inhaled long-acting antimuscarinic; an inhaled long-acting β2 agonist; and an inhaled corticosteroid;

wherein the subject is determined to have an increased level of expression of one or more genes of the first group of genes relative to a patient who has never been a smoker or an age-matched patient who has never been a smoker; or

ii) administering to the subject one or more of:

intensive smoking cessation therapy and an inhaled short-acting β2 agonist; wherein the subject is determined not to have an increased level of expression of one or more genes of the first group of genes relative to a patient who has never been a smoker or an age-matched patient who has never been a smoker.