US 12,329,730 B2
Thermoresponsive hydrogel containing polymer microparticles for controlled drug delivery
Morgan V. DiLeo, Mars, PA (US); Steven R. Little, Allison Park, PA (US); and Joel S. Schuman, New York, NY (US)
Assigned to University of Pittsburgh—Of the Commonweatlh System of Higher Education, Pittsburgh, PA (US)
Filed by UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US)
Filed on Sep. 12, 2022, as Appl. No. 17/942,486.
Application 17/942,486 is a division of application No. 16/772,107, granted, now 11,484,515, previously published as PCT/US2018/064707, filed on Dec. 10, 2018.
Claims priority of provisional application 62/597,770, filed on Dec. 12, 2017.
Prior Publication US 2023/0000802 A1, Jan. 5, 2023
Int. Cl. A61K 31/164 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 9/16 (2006.01); A61K 31/167 (2006.01); A61K 31/496 (2006.01); A61K 45/06 (2006.01); A61P 27/16 (2006.01)
CPC A61K 31/164 (2013.01) [A61K 9/0046 (2013.01); A61K 9/06 (2013.01); A61K 9/1647 (2013.01); A61K 31/167 (2013.01); A61K 31/496 (2013.01); A61P 27/16 (2018.01); A61K 45/06 (2013.01)] 36 Claims
OG exemplary drawing
 
1. A method for treating an ear condition in a subject, comprising topically administering to the ear of the subject in need thereof a composition comprising (i) anti-infective agent-loaded biodegradable polymer microparticles distributed within a thermoresponsive hydrogel; and (ii) an anesthetic distributed within the thermoresponsive hydrogel, wherein the anesthetic is lidocaine, benzocaine, or a combination thereof, and wherein the anesthetic is immediately released.