US 12,329,634 B2
Optical tissue measurement
Carolyn Sue Martinez, Santa Ana, CA (US)
Assigned to EDWARDS LIFESCIENCES CORPORATION, Irvine, CA (US)
Filed by Edwards Lifesciences Corporation, Irvine, CA (US)
Filed on Sep. 4, 2020, as Appl. No. 17/013,438.
Application 17/013,438 is a continuation of application No. PCT/US2019/020827, filed on Mar. 5, 2019.
Claims priority of provisional application 62/638,581, filed on Mar. 5, 2018.
Prior Publication US 2020/0397946 A1, Dec. 24, 2020
Int. Cl. A61F 2/24 (2006.01); A61L 27/24 (2006.01); A61L 27/36 (2006.01); A61L 31/00 (2006.01); G01N 21/21 (2006.01); G01N 21/59 (2006.01); G05B 19/4097 (2006.01)
CPC A61F 2/2415 (2013.01) [A61L 27/24 (2013.01); A61L 27/3625 (2013.01); A61L 27/3629 (2013.01); A61L 27/3691 (2013.01); A61L 31/005 (2013.01); G05B 19/4097 (2013.01); A61L 2430/20 (2013.01); G01N 21/21 (2013.01); G01N 21/5907 (2013.01); G05B 2219/36199 (2013.01); G05B 2219/45172 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for manufacturing a bioprosthetic tissue leaflet from a collagenous tissue, the method comprising:
illuminating a piece of tissue comprising collagen with a light source having a linear polarization;
passing light transmitted through the piece of tissue through a linear polarizer;
detecting a first pattern in the light passed through the linear polarizer;
determining a first orientation or a first density of collagen bundles in at least a portion of the piece of tissue from the first detected pattern;
after determining the first orientation or first density of the collagen bundles, rotating the linear polarizer and detecting a second pattern of light passed through the linear polarizer;
determining a second orientation or a second density of collagen bundles in at least a portion of the piece of tissue from the second detected pattern;
selecting an area on the piece of tissue for a bioprosthetic tissue leaflet based on the first and second orientations or densities of collagen bundles; and
cutting the bioprosthetic tissue leaflet including the selected area.