US 12,329,551 B2
Methods and systems for high performance and versatile molecular imaging
Michael Quinlan, San Francisco, CA (US); Lucian Mihailescu, Pleasant Hill, CA (US); and Andrei Claudiu Cosma, Emeryville, CA (US)
Assigned to Ziteo, Inc., Pleasant Hill, CA (US)
Filed by Ziteo, Inc., Pleasant Hill, CA (US)
Filed on Dec. 15, 2023, as Appl. No. 18/541,863.
Application 18/541,863 is a continuation of application No. 17/815,771, filed on Jul. 28, 2022, granted, now 11,883,214.
Application 17/815,771 is a continuation of application No. 17/594,192, granted, now 11,439,358, issued on Sep. 13, 2022, previously published as PCT/US2020/027526, filed on Apr. 9, 2020.
Claims priority of provisional application 62/836,514, filed on Apr. 19, 2019.
Claims priority of provisional application 62/831,504, filed on Apr. 9, 2019.
Prior Publication US 2024/0148346 A1, May 9, 2024
Int. Cl. A61B 6/03 (2006.01); A61B 6/00 (2024.01); A61B 6/42 (2024.01); G01T 1/29 (2006.01)
CPC A61B 6/037 (2013.01) [A61B 6/4258 (2013.01); A61B 6/4266 (2013.01); A61B 6/5235 (2013.01); G01T 1/295 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An imaging system comprising:
a gamma-ray photon sensor with energy and position resolution sensing capability, the sensor providing positions of photon interactions;
a coded aperture mask placed in front of the sensor, wherein the mask comprises mask pixel elements shaped as bifrustums, wherein a physical space between bifrustum mask pixel elements that have a common edge is partially or completely occupied by a material, and wherein the mask creates an imaging field of view in front of the sensor;
at least one processor; and
a memory operatively coupled with the sensor and the processor, the memory storing instructions for execution by the at least one processor that cause the processor to:
create a first projected photon interaction point on a plane of reference;
retrieve photon attenuation coefficients stored in the memory for the first projected interaction point for directions towards the imaging field of view;
create a second projected photon interaction point on a plane of reference;
retrieve photon attenuation coefficients stored in the memory for the second projected interaction point for directions towards the imaging field of view; and
reconstruct an image of a gamma-ray source using the retrieved attenuation coefficients for the first and second photon interactions.