US 12,329,528 B2
Probe arrays
Kilian Imfeld, Wädenswil (CH); Mauro Gandolfo, Zurich (CH); and Alessandro Maccione, Genoa (IT)
Assigned to 3Brain AG, Pfäffikon (CH)
Appl. No. 17/618,249
Filed by 3Brain AG, Pfäffikon (CH)
PCT Filed Jun. 10, 2020, PCT No. PCT/EP2020/066125
§ 371(c)(1), (2) Date Dec. 10, 2021,
PCT Pub. No. WO2020/249634, PCT Pub. Date Dec. 17, 2020.
Claims priority of application No. 1908326 (GB), filed on Jun. 11, 2019.
Prior Publication US 2022/0296149 A1, Sep. 22, 2022
Int. Cl. A61B 5/30 (2021.01); A61B 5/00 (2006.01); A61N 1/04 (2006.01)
CPC A61B 5/30 (2021.01) [A61B 5/7282 (2013.01); A61N 1/0476 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A microelectrode array for obtaining electrical signals from electrogenic cell material, comprising:
an array of electrodes,
each electrode having associated with it a sampling circuit for sampling an electrode signal on the electrode, and a sample buffer to store a representation of the electrode signal from the electrode,
each electrode further having associated with it an activity sensor configured to detect at least one electrode signal event above a predetermined threshold and to set at least one activity flag based on the detection;
the microelectrode array further comprising control logic to activate the sampling circuit and sample buffer of an electrode to sample the electrode signal and store a representation of the sampled electrode signal comprising plural samples of the electrode signal for that electrode only when the activity flag is set, wherein said control logic is configured to determine a duration of a sampling window based on the at least one activity flag and that follows the detected event, the duration comprising a period sufficient to capture said plural samples from the electrode.