US 12,329,496 B2
Spectral analysis of a sample
Philip Valmont Wilson, Mount Waverly (AU); William Parker, Oxford (GB); and Joao Mendes-Lopes, Lisbon (PT)
Assigned to Agilent Technologies LDA UK Limited, Cheadle (GB)
Appl. No. 17/925,272
Filed by Agilent Technologies LDA UK Limited, Cheadle (GB)
PCT Filed Mar. 2, 2021, PCT No. PCT/GB2021/050520
§ 371(c)(1), (2) Date Nov. 14, 2022,
PCT Pub. No. WO2021/229201, PCT Pub. Date Nov. 18, 2021.
Claims priority of application No. 2007136 (GB), filed on May 14, 2020.
Prior Publication US 2023/0218174 A1, Jul. 13, 2023
Int. Cl. A61B 5/00 (2006.01); G01J 3/02 (2006.01); G01J 3/44 (2006.01); G01J 3/45 (2006.01); G01J 3/453 (2006.01); G01N 21/31 (2006.01); G01N 21/3563 (2014.01); G01N 21/47 (2006.01); G01N 21/65 (2006.01); G01N 21/95 (2006.01); G01N 33/15 (2006.01)
CPC A61B 5/0075 (2013.01) [G01J 3/0205 (2013.01); G01J 3/0208 (2013.01); G01J 3/0216 (2013.01); G01J 3/0221 (2013.01); G01J 3/0229 (2013.01); G01J 3/0289 (2013.01); G01J 3/0297 (2013.01); G01J 3/44 (2013.01); G01J 3/4412 (2013.01); G01J 3/45 (2013.01); G01N 21/31 (2013.01); G01N 21/474 (2013.01); G01N 21/9508 (2013.01); G01N 33/15 (2013.01); G01J 2003/4538 (2013.01); G01N 21/3563 (2013.01); G01N 2021/4735 (2013.01); G01N 2021/4745 (2013.01); G01N 21/65 (2013.01)] 19 Claims
OG exemplary drawing
 
1. Apparatus for spectral analysis of a sample, wherein the sample is a pharmaceutical dosage form, comprising:
delivery optics arranged to direct probe light to a delivery region of the sample;
collection optics arranged to collect probe light scattered from a collection region of the sample; and
a spectrometer having an entrance port, the spectrometer being arranged to receive the collected probe light from the collection optics at the entrance port of the spectrometer, and to detect spectral features in the received probe light,
wherein the collection optics comprise Koehler integration optics arranged to process the collected probe light,
wherein the collection optics comprises a bundle of optical fibres having an entry face arranged to receive the collected probe light following processing by the Koehler integration optics, and an exit face arranged to deliver the collected probe light to the port of the spectrometer,
whereby the Koehler integration optics collect and process the scattered light such that the collected light from each point of the collection region is distributed across the entrance port of the spectrometer.