| CPC A61B 34/30 (2016.02) [A61B 34/10 (2016.02); A61B 34/20 (2016.02); A61B 90/14 (2016.02); A61B 17/1615 (2013.01); A61B 17/1703 (2013.01); A61B 2034/107 (2016.02); A61B 2034/2057 (2016.02)] | 18 Claims |

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1. A method of registering a patient anatomy comprising:
attaching, to a patient head, a reference fixture containing a plurality of radio-opaque fiducials visible in a medical image and a plurality of posts extending upward from the reference fixture;
obtaining the medical image of the patient anatomy with the attached reference fixture with a CT imaging device;
determining, through image processing, positions of the radio-opaque fiducials contained in the medical image;
obtaining positions of an end effector, having a guide tube, attached to a robot arm of a robot system based on contacting known reference points of the attached reference fixture with the end effector;
registering the robot system to the patient anatomy based on the determined positions of the radio-opaque fiducials contained in the medical image and on the obtained positions of the end effector,
wherein the guide tube includes an opening, and sequentially and physically receives in the guide tube opening each of the plurality of posts in order to register the robot system to the patient anatomy.
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