US 12,329,455 B2
Full-field optical coherence tomography imaging method
Viacheslav Mazlin, Paris (FR); Pedro Francisco Baracal De Mece, Neuilly-sur-seine (FR); and Albert Claude Boccara, Paris (FR)
Assigned to Paris Sciences et Lettres, (FR); Centre National de la Recherche Scientifique (CNRS), (FR); and Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris, (FR)
Appl. No. 17/786,714
Filed by Paris Sciences et Lettres, Paris (FR); Centre National de la Recherche Scientifique (CNRS), Paris (FR); and Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris, Paris (FR)
PCT Filed Dec. 18, 2020, PCT No. PCT/EP2020/087156
§ 371(c)(1), (2) Date Jun. 17, 2022,
PCT Pub. No. WO2021/123257, PCT Pub. Date Jun. 24, 2021.
Claims priority of application No. 19306683 (EP), filed on Dec. 18, 2019.
Prior Publication US 2023/0032722 A1, Feb. 2, 2023
Int. Cl. A61B 3/10 (2006.01); A61B 5/00 (2006.01)
CPC A61B 3/102 (2013.01) [A61B 5/0066 (2013.01)] 11 Claims
OG exemplary drawing
 
1. An imaging method,
the method performing a full-field optical coherence tomography imaging, FFOCT,
the method comprising acquiring a bidimensional en face FFOCT image of a layer of interest at a depth within a sample,
the method using a system comprising a FFOCT device,
the sample comprising the layer of interest that is to be imaged,
the FFOCT device comprising:
a spatially incoherent light source,
an imager,
a beam splitter defining a sample arm and a reference arm, the sample being arranged at an extremity of the sample arm,
wherein the method comprises:
simultaneously illuminating the sample arm and the reference arm at an illumination instant with an illuminating light emitted by the incoherent light source to generate sample light travelling from the sample into the extremity of the sample arm along a sample optical path and reference light traveling in the reference arm to the beam splitter along a reference optical path,
acquiring a bidimensional en face FFOCT image of the layer of interest with the imager from reference light and sample light combined in the beam splitter;
wherein the sample light contains interest light derived from the illuminating light emitted at the illumination instant and originating from the layer of interest of the sample, the interest light having travelled a first optical path length when entering the sample arm, the first optical path length having a curved profile of transverse variation distribution,
wherein reference light incident on the imager has travelled a reference optical path length along the reference optical path, and interest light incident on the imager has travelled a second optical path length,
wherein the reference arm comprises an optical curvature compensator that modifies a transverse variation distribution of the reference optical path length travelled by the reference light incident on the imager to compensate the curved profile of transverse variation distribution of the first optical path length, so that the transverse variation distribution of the reference optical path length travelled by the reference light incident on the imager and the transverse variation distribution of the first optical path length travelled by the interest light incident on the imager coincide, resulting in the interest light originating from the layer of interest interfering with the reference light and the imager imaging the layer of interest over a field of view of the imager to form the bidimensional en face FFOCT image acquired by the imager,
wherein the optical curvature compensator is a curved reflector having a curved reflecting surface, the curved reflector arranged at an end of the reference arm opposed to the beam splitter.